Tenofovir Disoproxil Fumarate



Tenofovir Disoproxil Fumarate





(te noe’ fo veer)

Viread

PREGNANCY CATEGORY B


Drug Classes

Antiviral

Nucleotide reverse transcriptase inhibitor


Therapeutic Actions

Antiviral activity; inhibits HIV reverse transcriptase activity, leading to a blocking of HIV reproduction.


Indications



  • Treatment of HIV-1 infection in combination with other antiretrovirals


  • Treatment of chronic hepatitis B in adults and children 12 yr and older weighing 35 kg or more



Contraindications and Cautions



  • Contraindicated with allergy to tenofovir or other components of the product; breast-feeding HIV patients


  • Use cautiously in pregnancy, hepatic or renal impairment, lactation (hepatitis B).


Available Forms

Tablets—150, 200, 250, 300 mg; power—40 mg/g


Dosages

Adults

300 mg/day PO without regard to food.

Pediatric patients 12 yr and older



  • Chronic hepatitis B (if weighing 35 kg or more): 300 mg/day PO.


  • HIV: 300 mg/day PO.

Pediatric patients 2–11 yr



  • HIV: 8 mg/kg/day PO.


  • Chronic hepatitis B: Not recommended.

Patients with renal impairment

Adjust dosage as follows:






















CrCl (mL/min) Dose (PO)
50 or more 300 mg every 24 hr
30–49 300 mg every 48 hr
10–29 300 mg twice a wk
Hemodialysis 300 mg every wk or after a total of about 12 hr of dialysis

Only gold members can continue reading. Log In or Register to continue

Related posts:

  1. Nitrates
  2. Aldesleukin
  3. Ampicillin
  4. Aztreonam

Stay updated, free articles. Join our Telegram channel
Tags:
Jul 21, 2016 | Posted by in NURSING | Comments Off on Tenofovir Disoproxil Fumarate

Full access? Get Clinical Tree
Get Clinical Tree app for offline access