Temazepam(te maz’ e pam)
Apo-Temazepam (CAN), CO Temazepam (CAN), Gen-Temazepam (CAN), Novo-Temazepam (CAN), PMS-Temazepam (CAN), ratio-Temazepam (CAN), Restoril
PREGNANCY CATEGORY X
CONTROLLED SUBSTANCE C-IV
Drug Classes
Benzodiazepine
Sedative-hypnotic
Therapeutic Actions
Exact mechanisms of action not understood; acts mainly at subcortical levels of the CNS, leaving the cortex relatively unaffected; main sites of action may be the limbic system and mesencephalic reticular formation; benzodiazepines potentiate the effects of GABA, an inhibitory neurotransmitter.
Indications
Short-term treatment of insomnia (7–10 days)
Contraindications and Cautions
Contraindicated with hypersensitivity to benzodiazepines, psychoses, acute narrow-angle glaucoma, shock, coma, acute alcoholic intoxication with depression of vital signs, pregnancy (risk of congenital malformations, neonatal withdrawal syndrome), labor and delivery (“floppy infant” syndrome), lactation (infants may become lethargic and lose weight).
Use cautiously with impaired liver or renal function, debilitation, depression, suicidal tendencies.
Available Forms
Capsules—7.5, 15, 22.5, 30 mg
Dosages
Adults
15–30 mg PO before bedtime; 7.5 mg may be sufficient for some patients.
Pediatric patients
Not for use in patients younger than 18 yr.
Geriatric or debilitated patients
Initially, 7.5 mg PO; adjust dosage, increasing if needed.
Pharmacokinetics
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