Telaprevir(tel a’ pre veer)
Incivek
PREGNANCY CATEGORY B
Drug Classes
Antiviral
Protease inhibitor
Therapeutic Actions
Antiviral; inhibits hepatitis C virus (HCV)–specific protease, which inhibits viral replication in the hepatitis C infected cell.
Indications
Treatment of chronic HCV, genotype-1 infection in adults with compensated liver disease who are previously untreated or who have failed on interferon and ribavirin therapy; must be given in combination with peginterferon alfa and ribavirin
Contraindications and Cautions
Contraindicated with history of serious hypersensitivity to telaprevir, concurrent use of CYP3A4/5 inducers or inhibitors, moderate to severe hepatic impairment, solid organ transplants, use of sildenafil or tadalafil for the treatment of pulmonary hypertension, pregnancy, lactation.
Use cautiously with coinfection with HIV, hepatitis B; elderly patients.
Available Forms
Tablets—375 mg
Dosages
Adults
750 mg PO tid (every 7–9 hr) with food for 12 wk; followed by 12–16 wk of peginterferon and ribavirin.
Pediatric patients
Safety and efficacy not established.
Pharmacokinetics
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Metabolism: Hepatic; T1/2: 9–11 hr
Distribution: May cross placenta; may enter breast milk
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