Sumatriptan Succinate(sue mah trip’ tan)
Alsuma, Apo-Sumatriptan (CAN), Gen-Sumatriptan (CAN), Imitrex, Novo-Sumatriptan (CAN), Novo-Sumatriptan DF (CAN), PMS-Sumatriptan (CAN), ratio-Sumatriptan (CAN), Sumavel DosePro, Zecuity
PREGNANCY CATEGORY C
Drug Classes
Antimigraine drug (triptan)
Serotonin-selective agonist
Therapeutic Actions
Binds to serotonin receptors to cause vascular constrictive effects on cranial blood vessels, causing the relief of migraine in selective patients.
Indications
Treatment of acute migraine attacks with or without aura (oral, nasal, subcutaneously)
Unlabeled use: Migraine headaches in children and adolescents
Contraindications and Cautions
Contraindicated with allergy to sumatriptan, cerebrovascular or peripheral vascular syndromes, severe hepatic impairment, MAOIs, uncontrolled hypertension, hemiplegic migraine, pregnancy, CAD
Use cautiously with the elderly, lactation, renal function impairment.
Available Forms
Tablets—25, 50, 100 mg; injection—4 mg/0.5 mL, 6 mg/0.5 mL; nasal spray—5 mg/0.1 mL, 20 mg/0.1 mL; needle-free injection system—4, 6 mg/0.5 mL; iontophoretic transdermal system—6.5 mg/4 hr
Dosages
Adults
Oral
25, 50, or 100 mg PO; additional doses may be repeated in 2 hr or more; up to a maximum of 200 mg/day.
Subcutaneous
6 mg subcutaneously, may be repeated in 1 hr. Maximum, 12 mg/24 hr. Needle-free autoinjector is available.
Intranasal
5, 10, or 20 mg spray into one nostril or 10 mg divided into two doses of 5 mg, one in each nostril, may be repeated after 2 hr. Maximum, 40 mg/24 hr.
Transdermal system
One system applied to dry, intact skin on upper arm or thigh. Once applied, activation button must be pushed. Leave in place for 4 hr or until red light goes out. No more than two systems should be used in 24 hr. Safety for use of more than four/mo has not been established.
Pediatric patients
Safety and efficacy not established.
Patients with hepatic impairment
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