Stavudine (d4T)(stay vyoo’ deen)
Zerit
PREGNANCY CATEGORY C
Drug Classes
Antiviral
Nucleoside reverse transcriptase inhibitor
Therapeutic Actions
Inhibits replication of some retroviruses, including HIV, HTLV III, LAV, and ARV.
Indications
Treatment of HIV-1 infection in combination with other antiretroviral therapy
Available Forms
Capsules—15, 20, 30, 40 mg; oral solution—1 mg/mL
Dosages
Adults
Weighing 60 kg or more: 40 mg PO every 12 hr.
Weighing less than 60 kg: 30 mg PO every 12 hr.
Pediatric patients older than 13 days
Weighing 60 kg or more: 40 mg PO every 12 hr.
Weighing 30 kg to less than 60 kg: 30 mg PO every 12 hr.
Weighing less than 30 kg: 1 mg/kg/dose PO every 12 hr.
Pediatric patients, birth to 13 days
0.5 mg/kg/dose PO every 12 hr.
Patients with renal impairment
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