Sertraline Hydrochloride



Sertraline Hydrochloride





(sir’ trah leen)

Apo-Sertraline (CAN), Novo-Sertraline (CAN), ratio-Sertraline (CAN), Zoloft

PREGNANCY CATEGORY C (FIRST TRIMESTER)

PREGNANCY CATEGORY D (THIRD TRIMESTER)


Drug Classes

Antidepressant

SSRI


Therapeutic Actions

Acts as an antidepressant by inhibiting CNS neuronal uptake of serotonin; blocks uptake of serotonin with little effect on norepinephrine, muscarinic, histaminergic, and alpha1-adrenergic or dopaminergic receptors.



Indications



  • Treatment of major depressive disorder


  • Treatment of OCD


  • Treatment of panic disorder with or without agoraphobia


  • Treatment of PTSD; long-term use to prevent relapse and sustain symptom improvement


  • Treatment of PMDD


  • Treatment of social anxiety disorder (social phobia)


  • Unlabeled uses: Nocturnal enuresis, hot flashes, cholestatic pruritus, migraine prevention, smoking cessation, traumatic brain injury



Available Forms

Tablets—25, 50, 100, 150, 200 mg; oral concentrate—20 mg/mL


Dosages

Adults



  • Major depressive disorder and OCD: Administer once a day, morning or evening. 50 mg PO daily; may be increased to up to 200 mg/day; dosage increases should not occur at intervals less than 1 wk.


  • Panic disorder and PTSD: 25 mg PO daily. After 1 wk increase to 50 mg once daily. Dose may be increased to 200 mg/day as needed.


  • PMDD: 50 mg/day PO daily or just during luteal phase of menstrual cycle. Range, 50–150 mg/day.


  • Social anxiety disorder: 25 mg/day PO; increase to 50 mg/day after 1 wk. Range, 50–200 mg/day.

Pediatric patients

Jul 21, 2016 | Posted by in NURSING | Comments Off on Sertraline Hydrochloride

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