Sertraline Hydrochloride(sir’ trah leen)
Apo-Sertraline (CAN), Novo-Sertraline (CAN), ratio-Sertraline (CAN), Zoloft
PREGNANCY CATEGORY C (FIRST TRIMESTER)
PREGNANCY CATEGORY D (THIRD TRIMESTER)
Drug Classes
Antidepressant
SSRI
Therapeutic Actions
Acts as an antidepressant by inhibiting CNS neuronal uptake of serotonin; blocks uptake of serotonin with little effect on norepinephrine, muscarinic, histaminergic, and alpha1-adrenergic or dopaminergic receptors.
Indications
Treatment of major depressive disorder
Treatment of OCD
Treatment of panic disorder with or without agoraphobia
Treatment of PTSD; long-term use to prevent relapse and sustain symptom improvement
Treatment of PMDD
Treatment of social anxiety disorder (social phobia)
Unlabeled uses: Nocturnal enuresis, hot flashes, cholestatic pruritus, migraine prevention, smoking cessation, traumatic brain injury
Contraindications and Cautions
Contraindicated with hypersensitivity to sertraline; concurrent use of MAOIs, pimozide, disulfiram (oral concentrate).
Use cautiously with impaired hepatic or renal function, pregnancy, lactation, latex sensitivity if using dropper dispenser.
Available Forms
Tablets—25, 50, 100, 150, 200 mg; oral concentrate—20 mg/mL
Dosages
Adults
Major depressive disorder and OCD: Administer once a day, morning or evening. 50 mg PO daily; may be increased to up to 200 mg/day; dosage increases should not occur at intervals less than 1 wk.
Panic disorder and PTSD: 25 mg PO daily. After 1 wk increase to 50 mg once daily. Dose may be increased to 200 mg/day as needed.
PMDD: 50 mg/day PO daily or just during luteal phase of menstrual cycle. Range, 50–150 mg/day.
Social anxiety disorder: 25 mg/day PO; increase to 50 mg/day after 1 wk. Range, 50–200 mg/day.
Pediatric patients
OCD:
6–12 yr: 25 mg PO once daily. May be increased slowly as needed. Maximum, 200 mg/day.
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