Ritonavir(ri ton’ ah veer)
Norvir
PREGNANCY CATEGORY B
Drug Class
Antiretroviral
Therapeutic Actions
Antiviral activity; inhibits HIV protease activity, leading to decrease in production of HIV particles.
Indications
Treatment of HIV infection in combination with other antiretrovirals
Contraindications and Cautions
Contraindicated with allergy to ritonavir, use of certain drugs (see Interactions).
Use cautiously with pregnancy, hepatic impairment, lactation.
Available Forms
Capsules—100 mg; tablets—100 mg; oral solution—80 mg/mL
Dosages
Adults
600 mg PO bid with food; 100–400 mg/day PO when used as a pharmacokinetic booster with other protease inhibitors.
Pediatric patients
Start at 250 mg/m2 PO bid and increase by 50 mg/m2 twice daily at 2–3 day intervals, to maximum of 400 mg/m2 PO bid; do not exceed 600 mg bid. Use in combination with other antiretrovirals.
Pharmacokinetics
Metabolism: Hepatic; T1/2: 3–5 hr
Distribution: May cross placenta; may enter breast milk
Excretion: Feces, urine
Adverse Effects
CNS: Asthenia, peripheral and circumoral paresthesias, anxiety, dreams, headache, dizziness, hallucinations, personality changes
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