Rifapentine(rif ah pin’ ten)
Priftin
PREGNANCY CATEGORY C
Drug Classes
Antibiotic
Antituberculotic
Therapeutic Actions
Inhibits DNA-dependent RNA polymerase activity in susceptible strains of Mycobacterium tuberculosis, causing cell death.
Indications
Treatment of pulmonary TB in conjunction with at least one other effective antituberculotic
Orphan drug use: Prophylaxis and treatment of Mycobacterium avium complex in patients with AIDS
Contraindications and Cautions
Contraindicated with allergy to any rifamycin, acute hepatic disease.
Use cautiously with pregnancy (teratogenic effects have been reported in preclinical studies), lactation, hepatic impairment.
Available Forms
Tablets—150 mg
Dosages
Adults
TB, intensive phase: 600 mg PO twice weekly with an interval of at least 72 hr between doses; continue for 2 mo. Always give rifapentine in combination with other antituberculotics.
Continuation phase: 600 mg PO once a wk for 4 mo in combination with other agents to which the organism is susceptible.
Pediatric patients
Safety and efficacy not established in patients younger than 12 yr.
Geriatric patients
Start at low end of dosing range; monitor patient closely.
Pharmacokinetics
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