
(ra nye’ te deen)
Apo-Ranitidine (CAN), CO Ranitidine (CAN), Gen-Ranitidine (CAN), Novo-Ranidine (CAN), Nu-Ranit (CAN), PMS-Ranitidine (CAN), ratio-Ranitidine (CAN), Zantac, Zantac EFFERdose, Zantac 75, Zantac 150
PREGNANCY CATEGORY B
Drug Classes
Gastric acid secretion inhibitor
Histamine-2 (H2) antagonist
Therapeutic Actions
Competitively inhibits the action of histamine at the H2 receptors of the parietal cells of the stomach, inhibiting basal gastric acid secretion and gastric acid secretion that is stimulated by food, insulin, histamine, cholinergic agonists, gastrin, and pentagastrin.
Indications
Short-term treatment of active duodenal ulcer
Maintenance therapy for duodenal ulcer at reduced dosage
Short-term treatment and maintenance therapy of active, benign gastric ulcer
Short-term treatment of GERD
Pathologic hypersecretory conditions (eg, Zollinger-Ellison syndrome) (adults only)
Treatment and maintenance of healing of erosive esophagitis
Treatment of heartburn, acid indigestion, sour stomach
Contraindications and Cautions
Contraindicated with allergy to ranitidine, lactation.
Use cautiously with impaired renal or hepatic function, pregnancy.
Available Forms
Tablets—75, 150, 300 mg; capsules—150, 300 mg; effervescent tablets—150 mg; syrup—15 mg/mL; oral solution—15 mg/mL; injection—25 mg/mL
Dosages
Adults
Active duodenal ulcer: 150 mg bid PO for 4–8 wk. Alternatively, 300 mg PO once daily at bedtime or 50 mg IM or IV every 6–8 hr or by intermittent IV infusion, diluted to 100 mL and infused over 15–20 min. Do not exceed 400 mg/day.
Maintenance therapy, duodenal ulcer: 150 mg PO at bedtime.
Maintenance therapy, gastric ulcer: 150 mg PO at bedtime.
Active erosive esophagitis or gastric ulcer: Initially, 150 mg PO qid with maintenance dose of 150 mg PO bid or 50 mg IM or IV every 6–8 hr.
Pathologic hypersecretory syndrome: 150 mg bid PO. Individualize the dose with patient’s response. Do not exceed 6 g/day.
GERD maintenance, esophagitis, benign gastric ulcer: 150 mg bid PO.Stay updated, free articles. Join our Telegram channel
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