Pyrazinamide(peer a zin’ a myde)
PREGNANCY CATEGORY C
Drug Class
Antituberculotic
Therapeutic Actions
Bacteriostatic or bacteriocidal against Mycobacterium tuberculosis; mechanism of action is unknown.
Indications
Initial treatment of active TB in adults and children when combined with other antituberculotics
Treatment of active TB after treatment failure with primary drugs
Treatment of drug-resistant TB as part of an individualized regimen
Contraindications and Cautions
Contraindicated with allergy to pyrazinamide, acute hepatic disease, lactation, acute gout.
Use cautiously with diabetes mellitus, acute intermittent porphyria, alcoholism, renal impairment, pregnancy.
Available Forms
Tablets—500 mg
Dosages
Adults and pediatric patients
15–30 mg/kg/day PO, given once a day; do not exceed 2 g/day. Always use with up to four other antituberculotics; administer for the first 2 mo of a 6-mo treatment program. 50–70 mg/kg PO twice weekly may increase compliance and is being studied as an alternative dosing schedule. Patients with HIV infection may require a longer course of therapy.
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