Prothrombin Complex Concentrate (Human)



Prothrombin Complex Concentrate (Human)





(pro throm’ ben)

Kcentra, Octaplex

PREGNANCY CATEGORY C


Drug Class

Vitamin K anticoagulant reversal agent


Therapeutic Actions

Pooled concentrate containing vitamin K–dependent clotting factors II, VII, IX, X, and antithrombotic proteins C and S. Provides preformed clotting factors for reversal of vitamin K antagonist–induced acute major bleeding in adults.


Indications



  • Urgent reversal of acquired coagulation factor deficiency induced by vitamin K antagonist therapy (warfarin) in adults with acute major bleeding



Available Forms

Single-use vials—400–620 units/vial (measured in units of factor IX)


Dosages

Adults

Base dosage on patient’s pretreatment INR. INR of 2 to less than 4, 25 units/kg IV; maximum, 2,500 units. INR of 4–6, 35 units/kg IV; maximum, 3,500 units. INR of more than 6, 50 units/kg IV; maximum, 5,000 units. Monitor INR during and after treatment.

Pediatric patients

Safety and efficacy not established.


Pharmacokinetics















Route Onset Peak
IV Rapid Varies with clotting factor

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Jul 21, 2016 | Posted by in NURSING | Comments Off on Prothrombin Complex Concentrate (Human)

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