Probenecid



Probenecid





(proe ben’ e sid)

Benuryl (CAN), Probalan

PREGNANCY CATEGORY B


Drug Classes

Antigout drug

Uricosuric drug


Therapeutic Actions

Inhibits the renal tubular reabsorption of urate, increasing the urinary excretion of uric acid, decreasing serum uric acid levels, retarding urate deposition, and promoting resorption of urate deposits; also inhibits the renal tubular reabsorption of most penicillins and cephalosporins.


Indications



  • Treatment of hyperuricemia associated with gout and gouty arthritis (adults)



  • Adjuvant to therapy with penicillins or cephalosporins, for elevation and prolongation of plasma levels of the antibiotic



Available Forms

Tablets—0.5 g


Dosages

Adults



  • Gout: 0.25 g PO bid for 1 wk; then 0.5 g PO bid. Maximum 2–3 g/day. For maintenance, continue dosage that maintains the normal serum uric acid levels. When no attacks occur for 6 mo or longer, decrease the daily dosage by 0.5 g every 6 mo.


  • Penicillin or cephalosporin therapy: 2 g/day PO in divided doses.


  • Gonorrhea treatment: Single 1-g dose PO 30 min before penicillin administration.

Pediatric patients 2 yr and older

Jul 21, 2016 | Posted by in NURSING | Comments Off on Probenecid

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