Prednisolone



Prednisolone





(pred niss’ oh lone)


Prednisolone

Oral: Prelone


Prednisolone Acetate

Ophthalmic solution: Omnipred, Pred Forte, Pred Mild, ratio-Prednisolone (CAN)

Oral: Flo-Pred


Prednisolone Sodium Phosphate

Oral: Hydrocortone, Orapred, Orapred ODT, Pediapred

PREGNANCY CATEGORY C

PREGNANCY CATEGORY D (FLO-PRED)


Drug Classes

Anti-inflammatory

Corticosteroid (intermediate-acting)

Glucocorticoid

Hormone


Therapeutic Actions

Enters target cells and binds to intracellular corticosteroid receptors, thereby initiating many complex reactions that are responsible for its anti-inflammatory and immunosuppressive effects.


Indications

Systemic



  • Hypercalcemia associated with cancer


  • Short-term management of various inflammatory and allergic disorders, such as rheumatoid arthritis, collagen diseases (eg, SLE), dermatologic diseases (eg, pemphigus), status asthmaticus, and autoimmune disorders


  • Hematologic disorders: Thrombocytopenia purpura, erythroblastopenia


  • Ulcerative colitis, acute exacerbations of MS and palliation in some leukemias and lymphomas


  • Trichinosis with neurologic or myocardial involvement


  • Prednisolone has weaker mineralocorticoid activity than hydrocortisone and is not used as physiologic replacement therapy

Ophthalmic



  • Inflammation of the lid, conjunctiva, cornea, and globe



Available Forms

Tablets—5 mg; rapidly dissolving tablets—10, 15, 30 mg; oral syrup—15 mg/5 mL, 5 mg/5 mL; ophthalmic suspension—0.12%, 1%; oral suspension—5, 15 mg/5 mL


Dosages

Adults

Individualize dosage, depending on severity of condition and patient’s response. Administer daily dose before 9 AM to minimize adrenal suppression. If long-term therapy is needed, consider alternate-day therapy. After long-term therapy, withdraw drug slowly to avoid adrenal insufficiency. For maintenance therapy, reduce initial dose in small increments at intervals until the lowest dose that maintains satisfactory clinical response is reached.

Oral

Prednisolone: 5–60 mg/day PO.

Jul 21, 2016 | Posted by in NURSING | Comments Off on Prednisolone

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