Posaconazole



Posaconazole





(pahs ah kon’ ah zall)

Noxafil

PREGNANCY CATEGORY C


Drug Class

Antifungal (triazole)


Therapeutic Actions

Inhibits the synthesis of ergosterol, a key component of the fungal cell membrane; this inhibition leads to inability of the fungus to form the fungal cell wall and results in cell death.


Indications



  • Prophylaxis of invasive Aspergillus and Candida infections in patients 13 yr and older
    who are at risk of developing these infections because they are immunosuppressed because of prolonged neutropenia from antineoplastic chemotherapy, graft-versus-host disease secondary to bone marrow transplants, or hematologic malignancies


  • Treatment of oropharyngeal candidiasis including cases refractory to itraconazole or fluconazole



Available Forms

Oral suspension—40 mg/mL


Dosages

Adults and children 13 yr and older



  • Prevention: 200 mg (5 mL) PO tid. Give with a full meal or liquid nutritional supplement.


  • Treatment: Loading dose of 100 mg (2.5 mL) PO bid on day 1; then 100 mg/day PO for 13 days. For refractory infection, 400 mg (10 mL) PO bid, with duration based on patient response.

Patients with hepatic impairment

Use cautiously and monitor closely.

Jul 21, 2016 | Posted by in NURSING | Comments Off on Posaconazole

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