Plasma Protein FractionPlasmanate, Plasma-Plex, Protenate
PREGNANCY CATEGORY C
Drug Classes
Blood product
Plasma protein
Therapeutic Actions
Maintains plasma colloid osmotic pressure and carries intermediate metabolites in the transport and exchange of tissue products; important in the maintenance of normal blood volume.
Indications
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Supportive treatment of shock due to burns, trauma, surgery, and infections
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Hypoproteinemia–nephrotic syndrome, hepatic cirrhosis, toxemia of pregnancy, postoperative patients, tuberculous patients, acute respiratory distress syndrome (ARDS), renal dialysis
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Acute liver failure
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Sequestration of protein-rich fluids
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Hyperbilirubinemia and erythroblastosis fetalis as an adjunct to exchange transfusions
Contraindications and Cautions
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Contraindicated with allergy to albumin, severe anemia, cardiac failure, normal or increased intravascular volume, current use of cardiopulmonary bypass, severe anemia.
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Use cautiously with hepatic or renal failure, hypertension, pregnancy.
Available Forms
Injection—5%
Dosages
Administer by IV infusion only. Contains 130–160 mEq sodium/L. Do not give more than 250 g in 48 hr; if it seems that more is required, patient probably needs whole blood or plasma.
Adults
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Hypovolemic shock: 250–500 mL IV as an initial dose. Do not exceed 10 mL/min. Adjust dosage based on patient response. Do not exceed 5–8 mL/min as plasma volume approaches normal.
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