Physiologic Adaptations With Aging
Barbara S. Levine
Aging is a normal developmental process during which physiological and psychosocial changes occur. Wide variation in the aging process exists among individuals as a result of varied environmental exposures, social relationships, genetic endowment, and health status. Whereas maximum lifespan (the age reached by the longest-lived survivors) for humans is 114 to 120 years, the average human lifespan is approximately 75 years. Developmental changes and adaptations continue throughout aging until death.
The lifespan is divided into phases, with the commonly used periods for these phases being infancy (birth to 1 year), early childhood (1 to 6 years), late childhood (7 to 10 years), adolescence (11 to 18 years), young adulthood (19 to 35 years), early middle age (36 to 49 years), late middle age (50 to 64 years), young-old (65 to 74 years), old (75 to 85 years), and old-old (86 years and older). The group of people who are aged 85 years or older is the most rapidly growing segment of the older population (Fig. 9-1). People in this age group typically have a noticeable decline in functional ability and have one or more chronic disorders.
Aging is a multifactorial process with genetic and environmental components. Each system in an organism, each tissue in a system, and each cell type in a tissue appear to have its own trajectory of aging.1 Theories of the biologic aspects of aging have been developed and studied.2 The theories can be divided into three groups: organ theories, physiological theories, and genome-based theories. The organ theories examine age changes in the body brought about by the possible initiation from a “master” organ system, such as the immune or neurological system. The physiologic theories analyze cell functioning as related to waste product accumulation or molecular changes. The genome-based theories attribute age changes to the individual’s genetic endowment and suggest that a predetermined series of events programmed into cells or random mutations or cell errors are responsible for the process of aging. Probably no one theory can totally explain the aging process, but some or all of these theories may be involved in the complete explanation.
The nurse needs to be aware of several concepts in addressing the health care needs of older adults.
Age-related changes are gradual and individual, and different systems age at different rates within an individual. There is more intra-individual variability among older people than there is among younger people.
Complex functions that require multisystem coordination show the most obvious decline and require the greatest compensation and support.
Vulnerability to disease increases with age.
Stressful situations (physiologic or psychosocial) produce a more pronounced reaction in the elderly and require a longer period of time for readjustment.3
Although Americans are living longer, they are not necessarily healthier. With increasing age, they are at increased risk for illness. Chronic illnesses, such as arthritis, cardiac and vascular problems, and diabetes, are the major health problems of older people (Fig. 9-2). Chronic illnesses do not occur in isolation; 80% of older Americans have one chronic illness and 50% have two or more. Because of the lifestyle changes in young and middle-aged adults, particularly in the areas of diet and exercise, in the near future, older adults may be sufficiently healthier that definitions and expectations of the aging process may need to be revised. At present, however, heart disease and stroke are the first and third leading cause of death of older adults (Fig. 9-3).
When older people become ill, there is frequently an atypical presentation, such as missing or altered symptoms. Confusion is often one of the earliest indications of a change in health status. Restlessness, confusion, or altered mentation often occur in the presence of illness and should not be confused with dementia, providing that dementia was not present before the illness. Acute onset or unexplained deterioration of health should be carefully evaluated and not accepted as a normal concomitant of aging.
The older person who is ill has many adjustments and adaptations to make. The social supports (family and friends) available to that person may be fewer or less able to be supportive because of their own debilities, such as a spouse who is also ill or an adult child who has other responsibilities. Apprehension, worry, and fear of becoming dependent and helpless may add to the emotional burden of the current illness. Of those older adults between 80 and 84 years of age, 30% require assistance with daily activities, and of those adults who are 85 years and older, 50% require assistance.
Older patients require careful, thorough nursing management during an acute illness and afterward. Discharge planning that begins with the admission process and includes consideration of living arrangements, care providers, and support services is especially important for older patients, who are often adversely affected by the shorter hospitalizations and fewer home nursing care visits that accompany changes in managed care.
GENERAL PHYSIOLOGIC CHANGES
Aging is an integral part of the continuum that begins at conception and ends at death. As contrasted with the developmental growth and maturation of childhood and adolescence, aging is characterized by a decline in function and by changes that are decremental in nature. The inability to maintain homeostasis in a broad range of environments and with a variety of physiologic challenges is central to the decline in function.
Changes related to aging may be classified or categorized in several ways. Kenny4 suggests the following scheme:
Change in which the function is totally lost (e.g., female reproductive ability)
Changes in or loss of function related to loss of structure (e.g., altered kidney function related to loss of nephrons)
Changes in efficiency without structural loss (e.g., reduction in conduction velocity in aging nerve fibers)
Changes resulting from interruptions in a control system (e.g., the increase in gonadotropins in women with the reduction in feedback control of sex hormones)
Rarely, increased function (e.g., secretion of antidiuretic hormone in response to osmotic challenge)
In reviewing the age-related changes in selected systems, the changes in structure and function of each system are discussed along with the clinical implications of the changes.
CARDIOVASCULAR CHANGES
One of the challenges in discussing aging changes in any system is that of separating changes that can be attributed only to age from changes related to disease. This is particularly true in the cardiovascular system. This discussion attempts to identify what is known about changes in cardiovascular structure and function that result from aging changes and, subsequently, increase vulnerability to disease.
Cardiac Structural Changes
Although there are some differences in findings, it is now agreed that there is myocardial hypertrophy from aging alone. Cross-sectional studies of normotensive subjects without cardiovascular disease indicate that left ventricular (LV) wall thickness increases progressively with age in men and women.5 The total number of LV myocytes decreases with advancing age.6 Some myocytes are lost because of apoptosis and are replaced by fibrous tissue. Age-related increases in the amount of collagen and changes in collagen structure (increased cross-linkages) occur within the myocardium.5 Surviving myocytes increase in size, producing age-related hypertrophy. A modest increase in LV cavitary size may occur and the cardiac silhouette may be enlarged slightly on the chest radiograph. These changes are within the clinically normal range.6
Changes in the myocardial cells include the accumulation of lipofuscin (a lipid-containing material), which is thought to be a consequence of biologic aging; deposits of amyloid and an increase in myocardial collagen and connective tissue.2,7 The effects of these changes on function are unclear but may contribute to increased ventricular stiffness associated with aging and with hypertension.
Aging changes in the valves are characterized by increases in fibrosis, collagen degeneration, lipid accumulation, and calcification. Calcifications of the aortic valve ring can contribute to stenosis and valvular incompetence in aging.7 Mitral annular calcification occurs more commonly in women than men over age
70 years. Mitral annular calcification contributes to mitral stenosis, mitral regurgitation, atrial arrhythmias, and heart block.8
70 years. Mitral annular calcification contributes to mitral stenosis, mitral regurgitation, atrial arrhythmias, and heart block.8
Cardiac Functional Changes
Changes in ventricular filling (preload) and diastolic function occur with aging. There is progressive slowing of the early diastolic filling rate coupled with augmented late diastolic filling.9 Augmentation of late diastolic filling results from vigorous atrial contraction and is accompanied by atrial enlargement. Despite these changes in filling, end-diastolic volume in the sitting or supine position is not usually reduced in women and is slightly increased in men.9 The change in end-diastolic volume from rest to exercise increases with age.10 This refutes the previously held belief that LV filling is impaired in the healthy, older heart.
Clinical implications of age-related changes in ventricular filling include greater dependence on atrial contraction, which is lost with atrial fibrillation and greater sensitivity to hypovolemia. The importance of adequate intravascular volume increases further with tachycardia, which limits filling time.
There is no change in resting systolic function, heart rate, or cardiac output during healthy aging.9 Maximum heart rate during dynamic exercise decreases with age (maximum heart rate = 220 – age). This age-related decrease in maximum heart rate explains the age-related decrease in maximum cardiac output in healthy people. Maximum cardiac output reserve is approximately 3.5-fold in younger and 2.5-fold in older people.9
Electrical System
Controversy and conflicting evidence exists about the effects of aging on the cardiac electrical system. In the absence of disease or extreme stress on the cardiac function, the electrical system is adequate for normal conductivity. Limited data support a marked age-associated increase in the prevalence and complexity of ventricular ectopy at rest and during exercise.9 Ventricular ectopic beats are evident on 24-hour ambulatory electrocardiogram in more than 75% of men and women aged greater than 64 years, with a somewhat higher prevalence in men than women.11 In 2% to 4% of asymptomatic, healthy older adults, 3 to 5 beat salvos of non-sustained ventricular tachycardia are present; runs of more than 5 beats are rare.