Paroxetine(pah rox’ a teen)
Paroxetine Hydrochloride
Apo-Paroxetine (CAN), CO Paroxetine (CAN), Gen-Paroxetine (CAN), Novo-Paroxetine (CAN), Paxil, Paxil CRDNC, ratio-Paroxetine (CAN)
Paroxetine Mesylate
Brisdelle, Pexeva
PREGNANCY CATEGORY D
Drug Classes
Antidepressant
SSRI
Therapeutic Actions
Potentiates serotonergic activity in the CNS, resulting in antidepressant effect.
Indications
Treatment of major depressive disorder
Treatment of OCD
Treatment of panic disorders
Treatment of social anxiety disorder (social phobia)
Treatment of generalized anxiety disorder
Treatment of PTSD
Treatment of PMDD
NEW INDICATION: Treatment of moderate to severe vasomotor symptoms (hot flashes) associated with menopause
Unlabeled uses: Diabetic neuropathy, traumatic brain injury, pruritus, stuttering; smoking cessation; prevention of migraines, IBS, nocturnal enuresis, insomnia
Contraindications and Cautions
Contraindicated with use of or within 14 days of use of MAOI, thioridazine, pimozide, linezolid, methylene blue.
Use cautiously in the elderly; with renal or hepatic impairment, pregnancy, lactation, suicidal patients.
Available Forms
Tablets—10, 20, 30, 40 mg; CR tabletsDNC—12.5, 25, 37.5 mg; capsules—75 mg; suspension—10 mg/5 mL
Dosages
Adults
Depression: 20 mg/day PO as a single daily dose. Range, 20–50 mg/day. Or 25–62.5 mg/day CR tablet.
OCD: 20 mg/day PO as a single dose, may increase in 10-mg/day increments; do not exceed 60 mg/day.
Panic disorder: 10 mg/day PO; increase in increments of 10 mg/wk; usual range, 10–60 mg/day. Or 12.5–75 mg/day PO CR tablet; do not exceed 75 mg/day.
Social anxiety disorder: 20 mg/day PO as a single dose in the morning. Or, 12.5 mg/day PO CR form. May increase up to 60 mg/day or 37.5 mg/day PO CR form.
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