Pantoprazole(pan toe’ pray zol)
Panto IV (CAN), Pantoloc (CAN), ProtonixDNC, Protonix IV
PREGNANCY CATEGORY B
Drug Classes
Antisecretory drug
Proton pump inhibitor
Therapeutic Actions
Gastric acid-pump inhibitor: Suppresses gastric acid secretion by specific inhibition of the hydrogen-potassium ATPase enzyme system at the secretory surface of the gastric parietal cells; blocks the final step of acid production.
Indications
Oral: Short-term (8 wk or less) and long-term treatment of GERD
Maintenance healing of erosive esophagitis
Long-term treatment of pathologic hypersecretory conditions
IV: Short-term (7–10 days) treatment of GERD in patients unable to continue oral therapy
IV: Treatment of pathologic hypersecretory conditions associated with Zollinger-Ellison syndrome and other neoplastic conditions
Unlabeled uses: Treatment of duodenal ulcer, prevention of GI bleeding in patients receiving antiplatelet drugs, laryngitis, prophylaxis for stress ulcer
Contraindications and Cautions
Contraindicated with hypersensitivity to any proton pump inhibitor or any drug components.
Use cautiously because of possible increased risk of Clostridium difficile infection.
Use cautiously with pregnancy, lactation.
Available Forms
DR tabletDNC—20, 40 mg; granules for oral suspension—40 mg/packet; powder for injection—40 mg/vial
Dosages
Adults
40 mg PO daily for short-term treatment and maintenance healing of erosive esophagitis for 8 wk or less. The 8-wk course may be repeated if healing has not occurred. Give continually for hypersecretory disorders: 40 mg/day IV bid, up to 240 mg/day (2-yr duration) or 40 mg/day IV for 7–10 days. For severe hypersecretory syndromes, 40 mg every 12 hr (up to 240 mg/day) PO or IV (6-day duration) has been used.
Pediatric patients 5 yr and older
Short-term treatment of GERD: 15 kg to less than 40 kg: 20 mg/day PO for up to 8 wk. 40 kg or more: 40 mg/day PO for up to 8 wk.
Patients with hepatic impairment
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