Oxybutynin Chloride(ox i byoo’ ti nin)
Apo-Oxybutynin (CAN), Ditropan XLDNC, Gelnique, Gen-Oxybutynin (CAN), Oxytrol, PMS-Oxybutynin (CAN)
PREGNANCY CATEGORY B
Drug Classes
Anticholinergic
Urinary antispasmodic
Therapeutic Actions
Acts directly to relax smooth muscle and inhibits the effects of acetylcholine at muscarinic receptors; reported to be less potent an anticholinergic than atropine but more potent as antispasmodic and devoid of antinicotinic activity at skeletal neuromuscular junctions or autonomic ganglia.
Indications
Relief of symptoms of bladder instability associated with voiding in patients with uninhibited neurogenic and reflex neurogenic bladder
ER tablets: Treatment of signs and symptoms of overactive bladder (incontinence, urgency, frequency); treatment of pediatric patients 6 yr and older with symptoms of detrusor overactivity associated with a neurologic condition, such as spina bifida (Ditropan XL)
Contraindications and Cautions
Contraindicated with allergy to oxybutynin, pyloric or duodenal obstruction, obstructive intestinal lesions or ileus, intestinal atony, megacolon, colitis, obstructive uropathies, glaucoma, myasthenia gravis, CV instability in acute hemorrhage, urinary retention.
Use cautiously with hepatic, renal impairment; pregnancy; lactation.
Available Forms
Tablets—5 mg; syrup—5 mg/5 mL; ER tabletsDNC—5, 10, 15 mg; transdermal patch—3.9 mg/day; topical gel—100 mg/g, 3%
Dosages
Adults
5 mg PO bid or tid. Maximum dose is 5 mg qid. ER tablets—5 mg PO daily, up to a maximum of 30 mg/day; transdermal patch—1 patch applied to dry, intact skin on the abdomen, hip, or buttock every 3–4 days (twice weekly); topical gel—apply 1 sachet (1 g) to thigh, abdomen, or upper arm once every 24 hr.
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