Most common bone cancer in children

Peak age late adolescence; rare in young children

Usually involves the diaphyseal long bones; about 50% of cases occur in femur but may also occur in tibia, humerus, fibula, ileum, vertebra, or mandible

Highly malignant; metastasizes quickly to the lungs

Survival rate about 60%; increases to 85% if nonmetastasized

Tumor arises from bone-forming osteoblast and bone-digesting osteoclast.

Unknown

Current theories: heredity, trauma, and excessive radiotherapy

Impaired mobility

Pain and swelling at the site