Prevention of chemotherapy-induced nausea and vomiting: Three 0.15 mg/kg doses IV: First dose is given over 15 min, beginning 30 min before chemotherapy; subsequent doses are given at 4 and 8 hr.

Prevention of nausea and vomiting associated with cancer chemotherapy: 8 mg PO 30 min prior to chemotherapy, then 8 mg 8 hr later; give 8 mg every 12 hr for 1–2 days after completion of chemotherapy. For highly emetogenic chemotherapy, give 24 mg PO 30 min before starting chemotherapy.

Prevention of nausea and vomiting associated with radiotherapy: 8 mg PO tid. For total-body radiotherapy, administer 1–2 hr before radiation each day. For single high-dose radiotherapy to abdomen, give 1–2 hr before radiotherapy, then every 8 hr for 1–2 days after completion of therapy. For daily fractionated radiotherapy to abdomen, give 1–2 hr before therapy, then every 8 hr for each day therapy is given.

Prevention of postoperative nausea and vomiting: 4 mg undiluted IV, preferably over 2–5 min, or as a single IM dose immediately before induction of anesthesia or 16 mg PO 1 hr before anesthesia.