Olmesartan Medoxomil(ol ma sar’ tan)
Benicar
PREGNANCY CATEGORY D
Drug Classes
Angiotensin II receptor antagonist (ARB)
Antihypertensive
Therapeutic Actions
Selectively blocks the binding of angiotensin II to specific tissue receptors found in the vascular smooth muscle and adrenal gland; this action blocks the vasoconstricting effect of the renin-angiotensin system as well as the release of aldosterone leading to decreased BP; may prevent the vessel remodeling associated with the development of atherosclerosis.
Indications
Treatment of hypertension, alone or in combination with other antihypertensives
Unlabeled use: Prevention of migraines
Contraindications and Cautions
Contraindicated with hypersensitivity to any component of the drug; pregnancy (use during the second or third trimester can cause injury or death to the fetus), lactation; concurrent use of aliskiren in diabetic patients.
Use cautiously with renal impairment, hypovolemia, salt depletion.
Available Forms
Tablets—5, 20, 40 mg
Dosages
Adults
20 mg/day PO as a once-daily dose; may titrate to 40 mg/day if needed after 2 wk.
Pediatric patients 6–16 yr
Weighing 35 kg or more: 20 mg/day PO initially; then titrate to maximum dose of 40 mg/day PO.
Weighing 20 to less than 35 kg: 10 mg/day PO initially; then titrate to maximum dose of 20 mg/day PO.
Pediatric patients younger than 6 yr
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