
(oh flox’ a sin)
Floxin, Floxin Otic, Ocuflox
PREGNANCY CATEGORY C
Drug Classes
Antibiotic
Fluoroquinolone
Therapeutic Actions
Bactericidal; interferes with DNA replication in susceptible gram-positive and gram-negative bacteria, preventing cell reproduction.
Indications
Acute bacterial exacerbations of COPD, community-acquired pneumonia caused by Haemophilus influenzae, Streptococcus pneumoniae
Acute, uncomplicated urethral and cervical gonorrhea due to Neisseria gonorrhoeae, nongonococcal urethritis, and cervicitis due
to Chlamydia trachomatis, mixed infections due to both
Uncomplicated skin and soft tissue infections due to Staphylococcus aureus, Streptococcus pyogenes, Proteus mirabilis
Uncomplicated UTIs caused by Citrobacter diversus, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and P. mirabilis caused by C. trachomatis and N. gonorrhoeae
Complicated UTIs caused by C. diversus, E. coli, K. pneumoniae, P. aeruginosa, P. mirabilis
Oral: Primary treatment of PID; complicated UTIs due to susceptible bacteria, including E. coli, K. pneumoniae, P. mirabilis, C. diversus, or P. aeruginosa
Prostatitis due to E. coli
Ophthalmic solution: Treatment of ocular infections caused by susceptible organisms
Orphan drug use: Treatment of bacterial corneal ulcers
Otic: Otitis externa (patients 6 mo and older), chronic suppurative otitis media (patients 12 yr and older), acute otitis media (patients 1 yr and older); once daily treatment of swimmer’s ear (otitis externa) caused by E. coli, P. aeruginosa, S. aureus (adults and children 6 mo and older)
Contraindications and Cautions
Contraindicated with allergy to fluoroquinolones, lactation, prolonged QT interval, history of myasthenia gravis.
Use cautiously with renal impairment, seizures, pregnancy.
Available Forms
Ophthalmic solution—3 mg/mL (0.3%); tablets—200, 300, 400 mg; otic solution—0.3%
Dosages
Adults
Uncomplicated UTIs: 200 mg every 12 hr PO for 3–7 days.
Complicated UTIs: 200 mg bid PO for 10 days.
Bacterial exacerbations of COPD, community-acquired pneumonia: 400 mg every 12 hr PO for 10 days.Stay updated, free articles. Join our Telegram channel
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