Norfloxacin(nor flox’ a sin)
Apo-Norflox (CAN), CO-Norfloxacin (CAN), Noroxin
PREGNANCY CATEGORY C
Drug Classes
Antibiotic
Fluoroquinolone
Urinary tract anti-infective
Therapeutic Actions
Bactericidal; interferes with DNA replication in susceptible gram-negative bacteria, leading to cell death.
Indications
For the treatment of adults with UTIs caused by susceptible bacteria, including Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter cloacae, Proteus vulgaris, Providencia rettgeri, Morganella morganii, Proteus aeruginosa, Citrobacter freundii, Staphylococcus aureus, S. epidermidis, group D streptococci
Uncomplicated urethral and cervical gonorrhea caused by Neisseria gonorrhoeae
Prostatitis caused by E. coli
Unlabeled uses: GI infections, traveler’s diarrhea
Contraindications and Cautions
Contraindicated with allergy to norfloxacin, nalidixic acid, or cinoxacin; lactation; history of tendinitis or tendon rupture; history of myasthenia gravis.
Use cautiously in patients with renal impairment, seizures, pregnancy.
Available Forms
Tablets—400 mg
Dosages
Adults
Uncomplicated UTIs: 400 mg every 12 hr PO for 7–10 days. Maximum dose, 800 mg/day.
Uncomplicated cystitis due to E. coli, K. pneumonia, or P. mirabilis: 400 mg every 12 hr PO for 3 days.
Complicated UTI: 400 mg PO every 12 hr for 10–21 days.
Uncomplicated gonorrhea: 800 mg PO as a single dose.
Prostatitis: 400 mg every 12 hr PO for 28 days.
Pediatric patients
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