Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
PREGNANCY CATEGORY B OR C
Therapeutic Actions
NSAIDs have anti-inflammatory, analgesic, and antipyretic activities largely related to inhibition of prostaglandin synthesis; exact mechanisms of action are not known.
Indications
Relief of signs and symptoms of rheumatoid arthritis, osteoarthritis, and juvenile arthritis
Relief of mild to moderate pain
Treatment of primary dysmenorrhea
Fever reduction
Reduction of number of adenomatous colorectal polyps in adults with familial adenomatous polyposis
Contraindications and Cautions
Contraindicated with allergy to salicylates or other NSAIDs (more common in patients with rhinitis, asthma, chronic urticaria, nasal polyps); CV dysfunction, hypertension; peptic ulceration, GI bleeding; pregnancy or lactation.
Use cautiously with impaired hepatic function, impaired renal function, heart failure.
Adverse Effects
CNS: Headache, dizziness, somnolence, insomnia, fatigue, tiredness, tinnitus, ophthalmologic effects
Dermatologic: Rash, pruritus, sweating, dry mucous membranes, stomatitis
GI: Nausea, dyspepsia, GI pain, diarrhea, vomiting, constipation, flatulence
GU: Dysuria, renal impairment
Hematologic: Bleeding, platelet inhibition with higher doses, neutropenia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia, agranulocytosis, granulocytopenia, aplastic anemia, decreased Hgb or Hct, bone marrow depression, menorrhagia
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