Nitroprusside Sodium



Nitroprusside Sodium





(nye troe pruss’ ide)

Nipride (CAN), Nitropress

PREGNANCY CATEGORY C


Drug Classes

Antihypertensive

Vasodilator


Therapeutic Actions

Acts directly on vascular smooth muscle to cause vasodilation (arterial and venous) and reduce BP. Mechanism involves interference with calcium influx and intracellular activation of calcium. CV reflexes are not inhibited and reflex tachycardia, increased renin release occur.


Indications



  • Hypertensive crises for immediate reduction of BP



  • Production of controlled hypotension during anesthesia to reduce bleeding in surgical procedures


  • Acute HF


  • Unlabeled uses: Acute MI, with dopamine; left ventricular failure, with oxygen, morphine, loop diuretic



Available Forms

Powder for injection—50 mg/vial


Dosages

Administer only by continuous IV infusion with sterile D5W.

Adults and pediatric patients

In patients not receiving antihypertensive medication, the average dose is 3 mcg/kg/min (range 0.3–10 mcg/kg/min). At this rate, diastolic BP is usually lowered by 30%–40% below pretreatment diastolic levels. Use smaller doses in patients on antihypertensive medication. Do not exceed infusion rate of 10 mcg/kg/min. If this rate of infusion does not reduce BP within 10 min, discontinue administration.

Geriatric patients or patients with renal impairment

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Jul 21, 2016 | Posted by in NURSING | Comments Off on Nitroprusside Sodium

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