Nisoldipine(nye sole’ di peen)
SularDNC
PREGNANCY CATEGORY C
Drug Classes
Antihypertensive
Calcium channel blocker
Therapeutic Actions
Inhibits the movement of calcium ions across the membranes of cardiac and arterial muscle cells; inhibits transmembrane calcium flow, which results in the depression of impulse formation in specialized cardiac pacemaker cells, slowing of the velocity of conduction of the cardiac impulse, depression of myocardial contractility, and dilation of coronary arteries and arterioles and peripheral arterioles; these effects in turn lead to decreased cardiac work, decreased cardiac energy consumption.
Indications
Essential hypertension, alone or in combination with other antihypertensives
Contraindications and Cautions
Contraindicated with allergy to nisoldipine, impaired hepatic function, sick sinus syndrome, HF, heart block (second- or third-degree).
Use cautiously with MI or severe CAD (increased severity of disease has occurred), lactation, pregnancy.
Available Forms
ER tabletsDNC—8.5, 17, 20, 25.5, 30, 34, 40 mg
Dosages
Adults
Initial dose of 17 mg PO daily; increase in weekly increments of 8.5 mg/wk until BP is controlled. Usual maintenance dose is 17–34 mg PO daily. Maximum dose, 34 mg/day.
Pediatric patients
Safety and efficacy not established.
Geriatric patients or patients with hepatic impairment
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