Naratriptan(nar ah trip’ tan)
Amerge
PREGNANCY CATEGORY C
Drug Classes
Antimigraine drug (triptan)
Serotonin selective agonist
Therapeutic Actions
Binds to serotonin receptors to cause vascular constrictive effects on cranial blood vessels, causing the relief of migraine in selective patients; migraine is believed to be caused by vasodilation of cranial blood vessels in these patients.
Indications
Treatment of acute migraine attacks with or without aura
Contraindications and Cautions
Contraindicated with allergy to any triptan, active CAD, uncontrolled hypertension, cerebrovascular disease or peripheral vascular syndromes, severe renal or hepatic impairment.
Use cautiously in the elderly; with lactation, pregnancy.
Available Forms
Tablets—1, 2.5 mg
Dosages
Adults
Single dose of 1 mg PO or 2.5 mg PO; may be repeated in 4 hr if needed. Do not exceed 5 mg/24 hr.
Pediatric patients
Safety and efficacy not established.
Patients with renal or hepatic impairment
Contraindicated in severe renal impairment (CrCl less than 15 mL/min) or severe hepatic impairment (Child-Pugh grade C). In mild or moderate renal or hepatic impairment, start with lowest dose and do not exceed 2.5 mg/24 hr.
