Nadolol(nay doe’ lol)
Corgard
PREGNANCY CATEGORY C
Drug Classes
Antianginal
Antihypertensive
Beta-adrenergic blocker (nonselective)
Therapeutic Actions
Competitively blocks beta-adrenergic receptors in the heart and juxtaglomerular apparatus, decreasing the influence of the sympathetic nervous system on these tissues and decreasing the excitability of the heart, cardiac output, oxygen consumption, renin release, and BP.
Indications
Hypertension, alone or with other drugs, especially diuretics
Long-term management of angina pectoris
Unlabeled use: Migraines
Contraindications and Cautions
Contraindicated with sinus bradycardia (HR less than 45 beats/min), second- or third-degree heart block (PR interval greater than 0.24 sec), cardiogenic shock, HF, asthma, COPD, lactation.
Use cautiously with diabetes or thyrotoxicosis, pregnancy.
Available Forms
Tablets—20, 40, 80, 120, 160 mg
Dosages
Adults
Hypertension: Initially, 40 mg PO daily; gradually increase dosage in 40- to 80-mg increments until optimum response is achieved. Usual maintenance dose is 40–80 mg/day; up to 320 mg daily may be needed. To discontinue, reduce dosage gradually over a 1- to 2-wk period.
Angina: Initially, 40 mg PO daily; gradually increase dosage in 40- to 80-mg increments at 3- to 7-day intervals until optimum response is achieved or heart rate markedly decreases. Usual maintenance dose is 40–80 mg daily; up to 240 mg/day may be
needed. Safety and efficacy of larger doses not established. To discontinue, reduce dosage gradually over 1- to 2-wk period.
Pediatric patients
Safety and efficacy not established.
Geriatric patients or patients with renal failure
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