Nadolol



Nadolol





(nay doe’ lol)

Corgard

PREGNANCY CATEGORY C


Drug Classes

Antianginal

Antihypertensive

Beta-adrenergic blocker (nonselective)


Therapeutic Actions

Competitively blocks beta-adrenergic receptors in the heart and juxtaglomerular apparatus, decreasing the influence of the sympathetic nervous system on these tissues and decreasing the excitability of the heart, cardiac output, oxygen consumption, renin release, and BP.


Indications



  • Hypertension, alone or with other drugs, especially diuretics


  • Long-term management of angina pectoris


  • Unlabeled use: Migraines



Available Forms

Tablets—20, 40, 80, 120, 160 mg


Dosages

Adults



  • Hypertension: Initially, 40 mg PO daily; gradually increase dosage in 40- to 80-mg increments until optimum response is achieved. Usual maintenance dose is 40–80 mg/day; up to 320 mg daily may be needed. To discontinue, reduce dosage gradually over a 1- to 2-wk period.


  • Angina: Initially, 40 mg PO daily; gradually increase dosage in 40- to 80-mg increments at 3- to 7-day intervals until optimum response is achieved or heart rate markedly decreases. Usual maintenance dose is 40–80 mg daily; up to 240 mg/day may be
    needed. Safety and efficacy of larger doses not established. To discontinue, reduce dosage gradually over 1- to 2-wk period.

Pediatric patients

Safety and efficacy not established.

Geriatric patients or patients with renal failure






















CrCl (mL/min) Dosage Intervals (hr)
More than 50 24
31–50 24–36
10–30 24–48
Less than 10 40–60

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Jul 21, 2016 | Posted by in NURSING | Comments Off on Nadolol

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