Moxifloxacin Hydrochloride(mocks ee flox’ a sin)
Avelox, Avelox IV, Moxeza, Vigamox
PREGNANCY CATEGORY C
Drug Classes
Antibiotic
Fluoroquinolone
Therapeutic Actions
Bactericidal; interferes with DNA replication, repair, transcription, and recombination in susceptible gram-negative and gram-positive bacteria, preventing cell reproduction and leading to cell death.
Indications
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Treatment of adults with community-acquired pneumonia caused by susceptible strains of Streptococcus pneumoniae (including multidrug resistant strains), Haemophilus influenzae, Mycoplasma pneumoniae, Chlamydia pneumoniae, Moraxella catarrhalis, Staphylococcus aureus, Klebsiella pneumoniae
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Treatment of bacterial sinusitis caused by S. pneumoniae, H. influenzae, M. catarrhalis
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Treatment of acute bacterial exacerbation of chronic bronchitis caused by S. pneumoniae, H. influenzae, H. parainfluenzae, K. pneumoniae, S. aureus, M. catarrhalis
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Treatment of uncomplicated skin and skin structure infections caused by S. aureus or Streptococcus pyogenes
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Treatment of complicated skin and skin structure infections and complicated intra-abdominal infections caused by methicillin–susceptible S. aureus, E. coli, K. pneumoniae, Enterobacter cloacae
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Treatment of bacterial conjunctivitis caused by susceptible strains of bacteria (ophthalmic solution)
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Unlabeled use: Hospital-acquired pneumonia, infective endocarditis in adults
Contraindications and Cautions
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Contraindicated with allergy to fluoroquinolones, prolonged QT interval, hypokalemia, pregnancy, lactation, history of myasthenia gravis.
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Use cautiously with hepatic impairment, seizures.
Available Forms
Tablets—400 mg; injection—400 mg in 250 mL; ophthalmic solution—0.5%
Dosages
Adults
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Pneumonia: 400 mg PO or IV daily for 7–14 days.
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Sinusitis: 400 mg PO or IV daily for 10 days.
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Acute exacerbation of chronic bronchitis: 400 mg PO or IV daily for 5 days.
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Uncomplicated skin and skin structure infections: 400 mg PO daily for 7 days.
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Complicated skin and skin structure infections: 400 mg PO or IV daily for 7–21 days.
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Complicated intra-abdominal infections: 400 mg PO or IV for 5–14 days.
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Bacterial conjuncitivitis: 1 drop in affected eye(s) bid for 7 days (Moxeza) or tid for 7 days (Vigamox).
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