
(mi noe sye’ kleen)
Apo-Minocycline (CAN), Arestin, Dynacin, Gen-Minocycline (CAN), Minocin, ratio-Minocycline (CAN), Solodyn
PREGNANCY CATEGORY D
Drug Classes
Antibiotic
Tetracycline
Therapeutic Actions
Bacteriostatic: Inhibits protein synthesis of susceptible bacteria, causing cell death.
Indications
Infections caused by rickettsiae; Mycoplasma pneumoniae; agents of psittacosis, ornithosis, lymphogranuloma venereum and granuloma inguinale; Borrelia recurrentis; Haemophilus ducreyi; Pasteurella pestis; Pasteurella tularensis; Bartonella bacilliformis; Bacteroides; Vibrio comma; Vibrio fetus; Brucella; Escherichia coli; Enterobacter aerogenes; Shigella; Acinetobacter calcoaceticus; Haemophilus influenzae; Klebsiella; Diplococcus pneumoniae; Staphylococcus aureus, Streptococcus pneumoniae
When penicillin is contraindicated, infections caused by Neisseria gonorrhoeae, Treponema pallidum, Treponema pertenue, Listeria monocytogenes, Clostridium, Bacillus anthracis, Fosobacterium fusiforme, Actinomyces israelii
As an adjunct to amebicides in acute intestinal amebiasis
Oral tetracyclines are indicated for treatment of severe acne, uncomplicated urethral, endocervical, or rectal infections in adults caused by Chlamydia trachomatis
Treatment of inflammatory lesions of nonnodule, moderate to severe acne vulgaris in patients 12 yr and older (ER tablets)
Oral minocycline is indicated in treatment of asymptomatic carriers of N. meningitidis (not useful for treating the infection); infections caused by Mycobacterium marinum; uncomplicated urethral, endocervical, or rectal infections caused by Ureaplasma urealyticum; uncomplicated gonococcal urethritis in men due to N. gonorrhoeae
Arestin: Adjunct to scaling and root planing to reduce pocket depth in patients with adult periodontitis
Unlabeled uses: Alternative to sulfonamides in the treatment of nocardiosis; treatment of early rheumatoid arthritis, gallbladder infection caused by Escherichia coli, infective endocarditis
Contraindications and Cautions
Contraindicated with allergy to tetracyclines.
Use cautiously with renal or hepatic impairment, pregnancy, lactation, asthma.
Available Forms
Capsules—50, 75, 100 mg; pellet-filled capsules—50, 100 mg; oral suspension—50 mg/5 mL; tablets—50, 75, 100 mg; sustained release microsphere—1 mg; ER tablets—45, 90, 135 mg; injection—100 mg/vial
Dosages
Adults
200 mg initially, followed by 100 mg every 12 hr PO. May be given as 100–200 mg initially and then 50 mg qid PO.
Syphilis: Usual PO dose for 10–15 days.Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree