Minocycline Hydrochloride



Minocycline Hydrochloride





(mi noe sye’ kleen)

Apo-Minocycline (CAN), Arestin, Dynacin, Gen-Minocycline (CAN), Minocin, ratio-Minocycline (CAN), Solodyn

PREGNANCY CATEGORY D


Drug Classes

Antibiotic

Tetracycline


Therapeutic Actions

Bacteriostatic: Inhibits protein synthesis of susceptible bacteria, causing cell death.


Indications



  • Infections caused by rickettsiae; Mycoplasma pneumoniae; agents of psittacosis, ornithosis, lymphogranuloma venereum and granuloma inguinale; Borrelia recurrentis; Haemophilus ducreyi; Pasteurella pestis; Pasteurella tularensis; Bartonella bacilliformis; Bacteroides; Vibrio comma; Vibrio fetus; Brucella; Escherichia coli; Enterobacter aerogenes; Shigella; Acinetobacter calcoaceticus; Haemophilus influenzae; Klebsiella; Diplococcus pneumoniae; Staphylococcus aureus, Streptococcus pneumoniae


  • When penicillin is contraindicated, infections caused by Neisseria gonorrhoeae, Treponema pallidum, Treponema pertenue, Listeria monocytogenes, Clostridium, Bacillus anthracis, Fosobacterium fusiforme, Actinomyces israelii


  • As an adjunct to amebicides in acute intestinal amebiasis


  • Oral tetracyclines are indicated for treatment of severe acne, uncomplicated urethral, endocervical, or rectal infections in adults caused by Chlamydia trachomatis


  • Treatment of inflammatory lesions of nonnodule, moderate to severe acne vulgaris in patients 12 yr and older (ER tablets)



  • Oral minocycline is indicated in treatment of asymptomatic carriers of N. meningitidis (not useful for treating the infection); infections caused by Mycobacterium marinum; uncomplicated urethral, endocervical, or rectal infections caused by Ureaplasma urealyticum; uncomplicated gonococcal urethritis in men due to N. gonorrhoeae


  • Arestin: Adjunct to scaling and root planing to reduce pocket depth in patients with adult periodontitis


  • Unlabeled uses: Alternative to sulfonamides in the treatment of nocardiosis; treatment of early rheumatoid arthritis, gallbladder infection caused by Escherichia coli, infective endocarditis



Available Forms

Capsules—50, 75, 100 mg; pellet-filled capsules—50, 100 mg; oral suspension—50 mg/5 mL; tablets—50, 75, 100 mg; sustained release microsphere—1 mg; ER tablets—45, 90, 135 mg; injection—100 mg/vial


Dosages

Adults

200 mg initially, followed by 100 mg every 12 hr PO. May be given as 100–200 mg initially and then 50 mg qid PO.

Jul 21, 2016 | Posted by in NURSING | Comments Off on Minocycline Hydrochloride

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