Miconazole Nitrate(mi kon’ a zole)
Topical: Breeze Mist Antifungal, Fungoid Tincture, Lotrimin AF, Tetterine
Vaginal suppositories topical: Micozole (CAN), Monistat 1, Monistat 1 Combination Pack, Monistat 1 Vaginal Ovule, Monistat 3, Monistat 3 Combination Pack, Monistat 3 Vaginal Ovule (CAN), Monistat 7, Monistat 7 Combination, Pack, Monistat/Day or Night Buccal Tablet, Oravig DNC
PREGNANCY CATEGORY B
Drug class
Antifungal
Therapeutic Actions
Fungicidal: Alters fungal cell membrane permeability, causing cell death; also may alter fungal cell DNA and RNA metabolism or cause accumulation of toxic peroxides intracellularly.
Indications
Vaginal suppositories: Local treatment of vulvovaginal candidiasis (moniliasis)
Topical administration: Tinea pedis, tinea cruris, tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum; cutaneous candidiasis (moniliasis), tinea versicolor
Contraindications and Cautions
Contraindicated with allergy to miconazole or components, including milk protein concentrate (Oravig) used in preparation.
Use cautiously with pregnancy, lactation.
Available Forms
Vaginal suppositories—100, 200, 1,200 mg; topical cream—2%; vaginal cream—2%; topical powder—2%; topical spray—1%, 2%; topical ointment—2%; spray powder or liquid—2%; solution—2%
Dosages
Adults
Vaginal suppositories
Monistat 3: Insert 1 suppository intravaginally once daily at bedtime for 3 days.
Monistat 7: One applicator cream or 1 suppository in the vagina daily at bedtime for 7 days. Repeat course if needed. Alternatively, one 1,200-mg suppository at bedtime for 1 dose.
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