Methylergonovine Maleate(meth ill er goe noe’ veen)
Methergine (CAN)
PREGNANCY CATEGORY C
Drug Classes
Ergot derivative
Oxytocic
Therapeutic Actions
A partial agonist or antagonist at alpha receptors; as a result, it increases the strength, duration, and frequency of uterine contractions, which shortens the third stage of labor and reduces blood loss.
Indications
Routine management after delivery of the placenta
Treatment of postpartum atony and hemorrhage; subinvolution of the uterus
Uterine stimulation during the second stage of labor following the delivery of the anterior shoulder, under strict medical supervision
Available Forms
Tablets—0.2 mg; injection—0.2 mg/mL
Dosages
Adults
IM
0.2 mg IM after delivery of the placenta, after delivery of the anterior shoulder, or during puerperium. May be repeated every 2–4 hr.
IV
Same dosage as IM; infuse slowly IV over at least 60 sec. Monitor BP very carefully as severe hypertensive reaction can occur; reserve this route for emergency situations.
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