Metaxalone(me tax’ ah lone)
Skelaxin
PREGNANCY CATEGORY C
Drug class
Skeletal muscle relaxant (centrally acting)
Therapeutic Actions
Precise mechanism of action not known, but may be due to general CNS depression; does not directly relax tense skeletal muscles or directly affect the motor endplate or motor nerves.
Indications
Adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal disorders
Contraindications and Cautions
Contraindicated with hypersensitivity to metaxalone; tendency for hemolytic or other anemias; severe renal or hepatic impairment, lactation.
Use cautiously with mild hepatic impairment, pregnancy.
Available Forms
Tablets—800 mg
Dosages
Adults and patients 12 yr and older
800 mg PO three to four times a day.
Pediatric patients younger than 12 yr
Not recommended.
Pharmacokinetics
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