Metaproterenol Sulfate(met a proe ter’ e nole)
Apo-Orciprenaline (CAN), ratio-Orciprenaline (CAN), Tanta-Orciprenaline (CAN)
PREGNANCY CATEGORY C
Drug Classes
Antiasthmatic
Beta2-selective adrenergic agonist
Bronchodilator
Sympathomimetic
Therapeutic Actions
In low doses, acts relatively selectively at beta2-adrenergic receptors to cause bronchodilation; at higher doses, beta2 selectivity is lost and the drug also acts at beta1 receptors to cause typical sympathomimetic cardiac effects.
Indications
Prophylaxis and treatment of bronchial asthma and reversible bronchospasm that may occur with bronchitis and emphysema
Contraindications and Cautions
Contraindicated with hypersensitivity to metaproterenol; tachyarrhythmias, tachycardia caused by digitalis intoxication.
Use cautiously with unstable vasomotor system disorders; hypertension; CAD; history of stroke; COPD in patients who have developed degenerative heart disease; hyperthyroidism; history of seizure disorders; psychoneurotic individuals; pregnancy; labor and delivery (may inhibit labor; parenteral use of beta2-adrenergic agonists can accelerate fetal heartbeat, cause hypoglycemia, hypokalemia, and pulmonary edema in the mother and hypoglycemia in the neonate); lactation.
Available Forms
Tablets—10, 20 mg; syrup—10 mg/5 mL
Dosages
Adults and children 12 yr and older
Oral
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