Meningitis
Life-threatening disorder
Description
Inflammation of brain and spinal cord meninges
Usually follows onset of respiratory symptoms
Sudden onset, causing serious illness within 24 hours
Good prognosis with viral meningitis; complications rare
If bacterial, causes acute infection in the subarachnoid space
Good prognosis if rare complications recognized early and infecting organism responsive to antibiotic therapy
In 10% to 15% of cases, bacterial meningitis fatal; sequelae common when occurring in the first 2 months of life
Condition common in infants and toddlers; incidence now greatly decreased with the routine administration of Haemophilus influenzae type B (Hib) vaccine
Pathophysiology
Viral or bacterial agents are transmitted by the spreading of droplets; organisms enter the blood from the nasopharynx or middle ear.
Inflammation may involve all three meningeal membranes ā the dura mater, the arachnoid, and the pia mater.
Causes
Aseptic meningitis ā viral (see Aseptic meningitis, page 140)
Vascular dissemination from focus of infection elsewhere in the body; infections possibly including or resulting from: