Meloxicam(mel ox’ i kam)
Apo-Meloxicam (CAN), Ava-Meloxicam (CAN), CO Meloxicam (CAN), Gen-Meloxicam (CAN), Mobic, Mobicox (CAN), Novo-Meloxicam (CAN), PMS-Meloxicam (CAN), ratio-Meloxicam (CAN)
PREGNANCY CATEGORY C
(FIRST AND SECOND TRIMESTERS)
PREGNANCY CATEGORY D
(THIRD TRIMESTER)
Drug class
NSAID (oxicam derivative)
Therapeutic Actions
Anti-inflammatory, analgesic, and antipyretic activities related to inhibition of the enzyme cyclooxygenase (COX), which is required for the synthesis of prostaglandins and thromboxanes. Somewhat more selective for COX-2 sites (found in the brain, kidneys, ovaries, uterus, cartilage, bone, and at sites of inflammation) than for COX-1 sites, which are found throughout the tissues and are related to protection of the GI mucosa.
Indications
Relief from the signs and symptoms of osteoarthritis and rheumatoid arthritis
Relief from the signs and symptoms of pauciarticular or polyarticular course juvenile rheumatoid arthritis in patients 2 yr or older
Unlabeled uses: Treatment of ankylosing spondylitis, acute shoulder pain
Contraindications and Cautions
Contraindicated with allergy to aspirin or meloxicam; for perioperative pain after coronary artery bypass surgery.
Use cautiously with allergies; renal, hepatic, CV, GI conditions; bleeding disorders; pregnancy; lactation.
Available Forms
Tablets—7.5, 15 mg; oral suspension—7.5 mg/5 mL
Dosages
Adults
Starting dose, 7.5 mg PO daily. Maximum dosage, 15 mg PO daily.
Pediatric patients 2 yr and older
0.125 mg/kg PO once daily up to a maximum dose of 7.5 mg, using oral suspension.
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