Lurasidone Hydrochloride(loo ras’ ih dohn)
Latuda
PREGNANCY CATEGORY B
Drug class
Atypical antipsychotic
Therapeutic Actions
Acts as an antagonist at central dopamine and serotonin receptor sites, which is thought to account for its antischizophrenic effects, although the actual mechanism of action is not understood.
Indications
Treatment of adults with schizophrenia
NEW INDICATION: Monotherapy or with valproate or lithium for adults with bipolar depression
Contraindications and Cautions
Contraindicated with history of serious hypersensitivity reactions to lurasidone; concurrent use of CYP3A4 inhibitors (such as ketoconazole) or inducers (such as rifampin); lactation.
Use cautiously with cardiovascular or cerebrovascular disorders, history of seizures, diabetes, liver or renal dysfunction, pregnancy.
Available Forms
Tablets—40, 80 mg
Dosages
Adults
Schizophrenia: Initially, 40 mg/day PO with food; may titrate to a maximum 160 mg/day PO with food. If administering with moderate CYP3A4 inhibitors (such as diltiazem and others), dosage should not exceed 40 mg/day.
Bipolar depression: Initially, 20 mg/day PO with food. May titrate to a maximum 120 mg/day PO with food.
Pediatric patients
Safety and efficacy not established.
Patients with moderate and severe renal impairment
Starting dose, 20 mg/day PO. Do not exceed 80 mg/day PO.
Patients with moderate to severe hepatic impairment
Starting dose, 20 mg/day PO. Do not exceed 80 mg/day (moderate impairment) or 40 mg/day (severe impairment).
Pharmacokinetics
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