Linezolid(lah nez’ oh lid)
Zyvox
PREGNANCY CATEGORY C
Drug class
Oxazolidinone antibiotic
Therapeutic Actions
Bacteriostatic and bacteriocidal: Interferes with protein synthesis on the bacterial ribosome; effective in VRE, Staphylococcus, and methicillin-resistant S. aureus (MRSA) and penicillin-resistant pneumococci and S. aureus; is a reversible, nonselective MAOI.
Indications
Treatment of infections due to vancomycin-resistant Enterococcus faecium (VREF)
Treatment of nosocomial and community-acquired pneumonia due to S. aureus and penicillin-susceptible Streptococcus pneumoniae
Treatment of complicated and uncomplicated skin and skin-structure infections including those caused by MRSA
Treatment of diabetic foot infections without osteomyelitis caused by gram-positive organisms including MRSA, Streptococcus pyogenes, or Streptococcus agalactiae
Contraindications and Cautions
Contraindicated with allergy to linezolid; lactation; phenylketonuria (oral suspension); concurrent use of MAOIs.
Use cautiously with bone marrow suppression, hepatic impairment, hypertension, hyperthyroidism, pheochromocytoma, carcinoid syndrome, pregnancy.
Available Forms
Tablets—600 mg; powder for oral suspension—100 mg/5 mL; injection—2 mg/mL
Dosages
No dosage adjustment is needed if switching between oral and IV forms.
Adults and children 12 yr and older
VREF, MRSA, pneumonia, complicated skin and skin structure infections, including diabetic foot ulcers without osteomyelitis: 600 mg IV or PO every 12 hr for 10–28 days, depending on infection.
Uncomplicated skin and skin structure infections: 400 mg PO every 12 hr for 10–14 days.
Pediatric patients
VREF, CAP, nosocomial pneumonia, complicated skin, and skin structure infections: 11 yr or younger: 10 mg/kg IV or PO every 8 hr for 10–14 days.
Uncomplicated skin and skin-structure infections: 5–11 yr: 10 mg/kg PO every 12 hr for 10–14 days. Younger than 5 yr: 10 mg/kg PO every 8 hr.
Pharmacokinetics
|
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
