Linezolid(lah nez’ oh lid)
Zyvox
PREGNANCY CATEGORY C
Drug class
Oxazolidinone antibiotic
Therapeutic Actions
Bacteriostatic and bacteriocidal: Interferes with protein synthesis on the bacterial ribosome; effective in VRE, Staphylococcus, and methicillin-resistant S. aureus (MRSA) and penicillin-resistant pneumococci and S. aureus; is a reversible, nonselective MAOI.
Indications
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Treatment of infections due to vancomycin-resistant Enterococcus faecium (VREF)
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Treatment of nosocomial and community-acquired pneumonia due to S. aureus and penicillin-susceptible Streptococcus pneumoniae
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Treatment of complicated and uncomplicated skin and skin-structure infections including those caused by MRSA
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Treatment of diabetic foot infections without osteomyelitis caused by gram-positive organisms including MRSA, Streptococcus pyogenes, or Streptococcus agalactiae
Contraindications and Cautions
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Contraindicated with allergy to linezolid; lactation; phenylketonuria (oral suspension); concurrent use of MAOIs.
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Use cautiously with bone marrow suppression, hepatic impairment, hypertension, hyperthyroidism, pheochromocytoma, carcinoid syndrome, pregnancy.
Available Forms
Tablets—600 mg; powder for oral suspension—100 mg/5 mL; injection—2 mg/mL
Dosages
No dosage adjustment is needed if switching between oral and IV forms.
Adults and children 12 yr and older
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VREF, MRSA, pneumonia, complicated skin and skin structure infections, including diabetic foot ulcers without osteomyelitis: 600 mg IV or PO every 12 hr for 10–28 days, depending on infection.
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Uncomplicated skin and skin structure infections: 400 mg PO every 12 hr for 10–14 days.
Pediatric patients
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VREF, CAP, nosocomial pneumonia, complicated skin, and skin structure infections: 11 yr or younger: 10 mg/kg IV or PO every 8 hr for 10–14 days.
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Uncomplicated skin and skin-structure infections: 5–11 yr: 10 mg/kg PO every 12 hr for 10–14 days. Younger than 5 yr: 10 mg/kg PO every 8 hr.
Pharmacokinetics
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