Letrozole(le’ tro zol)
Femara
PREGNANCY CATEGORY X
Drug Classes
Antiestrogen
Antineoplastic
Aromatase inhibitor
Therapeutic Actions
Inhibits the conversion of androgens to estrogens by the aromatase enzyme system (in postmenopausal women, the aromatase system is the main source of estrogens); reduces estrogen levels in all tissues, including tumors.
Indications
Treatment of advanced breast cancer in postmenopausal women as a first-line treatment and with disease progression following traditional antiestrogen therapy
Adjuvant treatment of early, receptor-positive breast cancer in postmenopausal women
Extended adjuvant treatment of breast cancer in postmenopausal women who have received 5 yr of tamoxifen therapy
Contraindications and Cautions
Contraindicated with allergy to letrozole, pregnancy.
Use cautiously with hepatic impairment, lactation.
Available Forms
Tablets—2.5 mg
Dosages
Adults
2.5 mg PO daily; continue until tumor progression is evident.
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