Isradipine(eyes rad’ i peen)
DynaCirc CRDNC
PREGNANCY CATEGORY C
Drug Classes
Antihypertensive
Calcium channel blocker
Therapeutic Actions
Inhibits the movement of calcium ions across the membranes of cardiac and arterial muscle cells; calcium is involved in the generation of the action potential in specialized automatic and conducting cells in the heart and in arterial smooth muscle and excitation-contraction coupling in cardiac muscle cells; inhibition of transmembrane calcium flow results in the depression of impulse formation in specialized cardiac pacemaker cells, slowing of the velocity of conduction of the cardiac impulse, the depression of myocardial contractility, and the dilation of coronary arteries and arterioles and peripheral arterioles. These effects lead to decreased cardiac work, cardiac energy consumption, and BP.
Indications
Management of hypertension alone or in combination with thiazide-type diuretics
Contraindications and Cautions
Contraindicated with allergy to isradipine; sick sinus syndrome, except with ventricular pacemaker; heart block (second or third degree); IHSS; cardiogenic shock.
Use cautiously in the elderly and with hypotension, impaired hepatic or renal function (repeated doses may accumulate), pregnancy, lactation, heart failure.
Available Forms
Capsules—2.5, 5 mg; CR tabletsDNC—5, 10 mg
Dosages
Adults
Initial dose of 2.5 mg PO bid. An antihypertensive effect is usually seen within 2–3 hr; maximal response may require 2–4 wk. Dosage may be increased in increments of 5 mg/day at 2- to 4-wk intervals. Maximum dose, 20 mg/day. CR: 5–10 mg PO daily as monotherapy or combined with thiazide diuretic.
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