Irbesartan(er bah sar’ tan)
Avapro
PREGNANCY CATEGORY D
Drug Classes
Antihypertensive
ARB
Therapeutic Actions
Selectively blocks the binding of angiotensin II to specific tissue receptors found in the vascular smooth muscle and adrenal gland; this action blocks the vasoconstriction effect of the renin-angiotensin system as well as the release of aldosterone, leading to decreased BP.
Indications
Treatment of hypertension as monotherapy or in combination with other antihypertensives
Slowing of the progression of nephropathy in patients with hypertension and type 2 diabetes
Contraindications and Cautions
Contraindicated with hypersensitivity to irbesartan, pregnancy (use during the second or third trimester can cause injury or even death to the fetus).
Use cautiously with hepatic or renal impairment, hypovolemia, volume or sodium depletion, lactation.
Available Forms
Tablets—75, 150, 300 mg
Dosages
Adults
Diabetic nephropathy: 300 mg/day PO as a single dose.
Hypertension: 150 mg PO daily as one dose; adjust slowly to determine effective dose; maximum daily dose, 300 mg.
Pediatric patients 13–16 yr
150 mg/day PO; maximum dose, 300 mg.
Pediatric patients 6–12 yr
75 mg/day PO, titrate to a maximum of 150 mg/day.
Pediatric patients younger than 6 yr
Not recommended.
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