Intrapleural Drug Administration

Intrapleural Drug Administration

An intrapleural drug is injected through the chest wall into the pleural space or instilled through a chest tube placed intrapleurally for drainage. Doctors use intrapleural administration to promote analgesia, treat spontaneous pneumothorax, resolve pleural effusions, and administer chemotherapy.

Intrapleurally administered drugs diffuse across the parietal pleura and innermost intercostal muscles to affect the intercostal nerves. During intrapleural injection of a drug, the needle passes through the intercostal muscles and parietal pleura on its way to the pleural space.

Drugs commonly given by intrapleural injection include tetracycline, streptokinase, anesthetics, and chemotherapeutic agents (to treat malignant pleural effusion or lung adenocarcinoma).

Contraindications for this route include pleural fibrosis or adhesions, which interfere with diffusion of the drug to the intended site; pleural inflammation; sepsis; and infection at the puncture site. Patients with bullous emphysema and those receiving respiratory therapy using positive end-expiratory pressure also shouldn’t have intrapleural injections because the injections may exacerbate an already compromised pulmonary condition.

Preparation of Equipment

When administering chemotherapy, make sure a spill kit is readily available to clean up spills immediately should they occur.

Jul 21, 2016 | Posted by in NURSING | Comments Off on Intrapleural Drug Administration

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