Ibuprofen(eye byoo’ proe fen)
Advil, Advil Liqui-Gels, Advil Migraine, Advil Pediatric Drops, Apo-Ibuprofen (CAN), Apo-Ibuprofen Prescription (CAN), Caldolor, Children’s, Advil, Children’s Motrin, Ibutab, Infants’ Motrin, Junior Strength Motrin, Midol Maximum Strength Cramp Formula, Motrin, Motrin IB, Motrin, Migraine Pain, PediaCare Fever, Pediatric Advil Drops
PREGNANCY CATEGORY B
PREGNANCY CATEGORY D
(THIRD TRIMESTER)
Drug Classes
Analgesic (nonopioid)
NSAID
Propionic acid derivative
Therapeutic Actions
Anti-inflammatory, analgesic, and antipyretic activities largely related to inhibition of prostaglandin synthesis; exact mechanisms of action are not known. Inhibits both cyclooxygenase (COX) 1 and 2. Ibuprofen is slightly more selective for COX-1.
Indications
Relief of signs and symptoms of rheumatoid arthritis and osteoarthritis
Relief of mild to moderate pain
Treatment of primary dysmenorrhea
Prevention and treatment of migraine headache
Fever reduction
Unlabeled use: Prevention of adverse reactions with DTP vaccine in patients at risk for seizures
Contraindications and Cautions
Contraindicated with allergy to ibuprofen, salicylates, or other NSAIDs (more common in patients with rhinitis, asthma, chronic urticaria, nasal polyps), perioperative CABG pain.
Use cautiously with CV dysfunction, hypertension, peptic ulceration, GI bleeding, pregnancy, lactation, impaired hepatic or renal function.
Available Forms
Tablets—100, 200, 400, 600, 800 mg; chewable tablets—50, 100 mg; capsules—200 mg; suspension—100 mg/2.5 mL, 100 mg/5 mL; oral drops—40 mg/mL; injection—10 mg/mL, 100 mg/mL
Dosages
Adults
Do not exceed 3,200 mg/day.
Mild to moderate pain: 400 mg every 4–6 hr PO.
Migraine: 400 mg PO at onset of headache.
Osteoarthritis or rheumatoid arthritis: 1,200–3,200 mg/day PO (300 mg qid or 400, 600, 800 mg tid or qid; individualize dosage. Therapeutic response may occur in a few days, but often takes 2 wk).
Primary dysmenorrhea: 400 mg every 4 hr PO.
IV use: 400–800 mg IV over 30 min every 6 hr for pain; 400 mg IV over 30 min for fever, can be followed by 400 mg every 4–6 hr or 100–200 mg every 4 hr to control fever.
OTC use: 200–400 mg every 4–6 hr PO while symptoms persist; do not exceed 1,200 mg/day. Do not take for more than 10 days for pain or 3 days for fever, unless so directed by health care provider.
Pediatric patients 6 mo–11 yr
Give dose every 6–8 hr according to weight (shown below) but no more than four times/day.
|
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
