HydrOXYzine(hye drox’ i zeen)
HydrOXYzine
Hydrochloride
Oral preparations: Apo-Hydroxyzine (CAN), Vistaril
Parenteral preparations: Vistaril
HydrOXYzine Pamoate
Oral preparation: Vistaril
PREGNANCY CATEGORY C
Drug Classes
Antiemetic
Antihistamine
Anxiolytic
Therapeutic Actions
Mechanisms of action not understood; actions may be due to suppression of subcortical areas of the CNS; has clinically demonstrated antihistaminic, analgesic, antispasmodic, antiemetic, mild antisecretory, and bronchodilator activity.
Indications
Symptomatic relief of anxiety and tension associated with psychoneurosis; adjunct in organic disease states in which anxiety is manifested; alcoholism and asthma; before dental procedures
Management of pruritus due to allergic conditions, such as chronic urticaria, atopic and contact dermatosis, and in histamine-mediated pruritus
Sedation when used as premedication and following general anesthesia
Control of nausea and vomiting and as adjunct to analgesia preoperatively and postoperatively to allow decreased opioid dosage
Management of the acutely disturbed or hysterical patient; the acute or chronic alcoholic with anxiety withdrawal symptoms or delirium tremens; as preoperative and postoperative adjunct to permit reduction in opioid dosage, allay anxiety, and control emesis
Contraindications and Cautions
Contraindicated with allergy to hydroxyzine or cetirizine; pregnancy, lactation.
Use cautiously with uncomplicated vomiting in children (may contribute to Reye syndrome or unfavorably influence its outcome; extrapyramidal effects may obscure diagnosis of Reye syndrome).
