Gemifloxacin Mesylate(jem ah flox’ a sin)
FactiveDNC
PREGNANCY CATEGORY C
Drug Classes
Antibiotic
Fluoroquinolone
Therapeutic Actions
Bactericidal; interferes with DNA replication, repair, transcription, and recombination in susceptible gram-negative and gram-positive bacteria, preventing cell reproduction and leading to cell death.
Indications
Treatment of acute bacterial exacerbation of chronic bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae, H. parainfluenzae, Moraxella catarrhalis
Treatment of community-acquired pneumonia caused by S. pneumoniae (including multi-drug–resistant strains), H. influenzae, Moraxella catarrhalis, Mycoplasma pneumonia, Chlamydia pneumoniae, Klebsiella pneumoniae
Contraindications and Cautions
Contraindicated with history of sensitivity to gemifloxacin or any fluoroquinolone antibiotic; history of tendinitis, tendon rupture; history of prolonged QTc interval; uncorrected hypokalemia or hypomagnesemia; use of quinidine, procainamide, amiodarone, or sotalol antiarrhythmics.
Use cautiously with epilepsy or predisposition to seizures; pregnancy; lactation.
Available Forms
TabletsDNC—320 mg
Dosages
Adults
Acute bacterial exacerbation of chronic bronchitis: 320 mg/day PO for 5 days.
Community-acquired pneumonia: 320 mg/day PO for 5 days for known or suspected S. pneumoniae, H. influenzae, M. pneumoniae, or C. pneumoniae and 7 days for known or suspected multi-drug–resistant S. pneumoniae, K. pneumoniae, or M. catarrhalis.
Pediatric patients
Safety and efficacy not established.
Patients with renal impairment
For CrCl greater than 40 mL/min, use usual dose; for CrCl of 40 mL/min or less, use 160 mg/day PO.
Pharmacokinetics
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