Gabapentin EnacarbilHorizantDNC
PREGNANCY CATEGORY C
Drug class
Antiepileptic
Therapeutic Actions
Mechanism of action not understood; antiepileptic activity may be related to its ability to inhibit polysynaptic responses and block posttetanic potentiation.
Indications
Adjunctive therapy in the treatment of partial seizures with and without secondary generalization in adults and children older than 12 yr with epilepsy
Adjunctive therapy for treatment of partial seizures in children 3–12 yr
Orphan drug use: Treatment of amyotrophic lateral sclerosis
Management of post-herpetic neuralgia in adults
Treatment of moderate to severe primary restless legs syndrome in adults (Horizant)
Unlabeled uses: Hot flashes, neuropathic pain, diabetic neuropathy, pruritus
Contraindications and Cautions
Contraindicated with hypersensitivity to gabapentin.
Use cautiously with pregnancy, lactation.
Available Forms
Capsules—100, 300, 400 mg; tablets—100, 300, 400, 600, 800 mg; oral solution—250 mg/5 mL; ER tablets—600 mgDNC; tabletsDNC—300, 600 mg (Gralise)
Dosages
Adults
Epilepsy: Starting dose is 300 mg PO tid, then titrated up as needed. Maintenance: 900–1,800 mg/day PO in divided doses tid PO; maximum interval between doses should not exceed 12 hr. Up to 2,400–3,600 mg/day has been used
Post-herpetic neuralgia: Initial dose of 300 mg/day PO; 300 mg bid PO on day 2; 300 mg tid PO on day 3. Or, 1,800 mg/day PO with the evening meal (Gralise).
Moderate to severe restless legs syndrome: 600–800 mg/day PO with food, around 5 PM; maximum dose, 2,400 mg/day (Horizant).
Pediatric patients 3–12 yr
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