Fluvastatin Sodium(flue va sta’ tin)
Lescol, Lescol XLDNC
PREGNANCY CATEGORY X
Drug Classes
Antihyperlipidemic
Statin
Therapeutic Actions
Inhibits the enzyme HMG-CoA that catalyzes the first step in the cholesterol synthesis pathway, resulting in a decrease in serum cholesterol, serum LDL (associated with increased risk of CAD), and either an increase or no change in serum HDL (associated with decreased risk of CAD).
Indications
Adjunct to diet in the treatment of elevated total cholesterol and LDL cholesterol with primary hypercholesterolemia and mixed dyslipidemia (types IIa and IIb) where response to dietary restriction of saturated fat and cholesterol and other nonpharmacologic measures has not been adequate
To slow progression of coronary atheroscleroses in patients with CAD, along with diet and exercise
Reduction of the risk of undergoing coronary revascularization procedures in patients with CAD
Treatment of heterozygous familial hypercholesterolemia in children 9–16 yr
Contraindications and Cautions
Contraindicated with allergy to fluvastatin, allergy to fungal byproducts, pregnancy, lactation.
Use cautiously with impaired hepatic function, cataracts, myopathy.
Available Forms
Capsules—20, 40 mg; extended-release tabletsDNC—80 mg
Dosages
Adults
Initial dosage, 40 mg/day PO administered in the evening. Maintenance doses, 20–80 mg/day PO; give 80 mg/day as two 40-mg doses, or use 80-mg ER form.
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