Fluoroquinolones
PREGNANCY CATEGORY C
Therapeutic Actions
Fluoroquinolones are antibacterial. They interfere with DNA replication in susceptible gram-negative bacteria, preventing cell reproduction and leading to death of bacteria.
Indications
Treatment of infections caused by susceptible gram-negative bacteria, including Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter cloacae, Proteus vulgaris, Providencia rettgeri, Morganella morganii, Pseudomonas aeruginosa, Citrobacter freundii, Staphylococcus aureus, S. epidermidis, group D streptococci, Streptococcus pneumoniae
Unlabeled use: Treatment of patients with cystic fibrosis who have pulmonary exacerbations, treatment after anthrax exposure
Contraindications and Cautions
Contraindicated with allergy to any fluoroquinolone, pregnancy, lactation, history of myasthenia gravis.
Use cautiously with renal impairment, seizures.
Adverse Effects
CNS: Headache, dizziness, insomnia, fatigue, somnolence, depression, blurred vision
GI: Nausea, vomiting, dry mouth, diarrhea, abdominal pain
Hematologic: Elevated BUN, AST, ALT, serum creatinine and alkaline phosphatase; decreased WBC, neutrophil count, Hct
Other: Fever, rash, photosensitivity, QT-interval prolongation, tendinitis, tendon rupture
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