Flunisolide(floo niss’ oh lide)
Aerospan HFA, Apo-Flunisolide (CAN), ratio-Flunisolide (CAN)
PREGNANCY CATEGORY C
Drug Classes
Corticosteroid
Glucocorticoid
Hormone
Therapeutic Actions
Anti-inflammatory effect; local administration into lower respiratory tract or nasal passages maximizes beneficial effects while decreasing possible adverse effects from systemic absorption.
Indications
Intranasal: Relief and management of nasal symptoms of seasonal or perennial allergic rhinitis
Inhalation: Maintenance treatment of asthma
Contraindications and Cautions
Contraindicated with systemic fungal infections, untreated local nasal infections, epistaxis, nasal trauma, septal ulcers, recent nasal surgery.
Use cautiously with pregnancy, lactation, status asthmaticus.
Available Forms
Intranasal solution, spray—25 mcg/actuation; inhalation—80 mcg/actuation
Dosages
Intranasal
Each actuation of the inhaler delivers 25 mcg.
Adults
Initial dosage, two sprays (50 mcg) in each nostril bid (total dose 200 mcg/day); may be increased to two sprays in each nostril tid (total dose 300 mcg/day). Maximum daily dose, eight sprays in each nostril (400 mcg/day).
Pediatric patients 6–14 yr
Initial dosage, one spray in each nostril tid or two sprays in each nostril bid (total dose 150–200 mcg/day). Maximum daily dose, four sprays in each nostril (200 mcg/day). For maintenance dosage, reduce to smallest effective dose. Discontinue therapy after 3 wk if no significant symptomatic improvement.
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